Detalhe da pesquisa
1.
High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo.
J Biol Chem
; 300(2): 105618, 2024 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-38176652
2.
Variations of the Mycobacterium abscessus F-ATP synthase subunit a-c interface alter binding and potency of the anti-TB drug bedaquiline.
Biochem Biophys Res Commun
; 690: 149249, 2024 Jan 01.
Artigo
Inglês
| MEDLINE | ID: mdl-38000294
3.
Atomic insights of an up and down conformation of the Acinetobacter baumannii F1 -ATPase subunit ε and deciphering the residues critical for ATP hydrolysis inhibition and ATP synthesis.
FASEB J
; 37(7): e23040, 2023 07.
Artigo
Inglês
| MEDLINE | ID: mdl-37318822
4.
Anti-Mycobacterium abscessus Activity of Tuberculosis F-ATP Synthase Inhibitor GaMF1.
Antimicrob Agents Chemother
; 66(5): e0001822, 2022 05 17.
Artigo
Inglês
| MEDLINE | ID: mdl-35481752
5.
Structural Elements Involved in ATP Hydrolysis Inhibition and ATP Synthesis of Tuberculosis and Nontuberculous Mycobacterial F-ATP Synthase Decipher New Targets for Inhibitors.
Antimicrob Agents Chemother
; 66(12): e0105622, 2022 12 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36445139
6.
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents.
Bioorg Med Chem
; 74: 117046, 2022 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-36228522
7.
Targeting the menaquinol binding loop of mycobacterial cytochrome bd oxidase.
Mol Divers
; 25(1): 517-524, 2021 Feb.
Artigo
Inglês
| MEDLINE | ID: mdl-31939065
8.
TBAJ-876 Displays Bedaquiline-Like Mycobactericidal Potency without Retaining the Parental Drug's Uncoupler Activity.
Antimicrob Agents Chemother
; 64(2)2020 01 27.
Artigo
Inglês
| MEDLINE | ID: mdl-31712198
9.
Discovery of a Novel Mycobacterial F-ATP Synthase Inhibitor and its Potency in Combination with Diarylquinolines.
Angew Chem Int Ed Engl
; 59(32): 13295-13304, 2020 08 03.
Artigo
Inglês
| MEDLINE | ID: mdl-32337801
10.
TBAJ-876 Retains Bedaquiline's Activity against Subunits c and ε of Mycobacterium tuberculosis F-ATP Synthase.
Antimicrob Agents Chemother
; 63(10)2019 10.
Artigo
Inglês
| MEDLINE | ID: mdl-31358589
11.
Structure and function of Mycobacterium-specific components of F-ATP synthase subunits α and ε.
J Struct Biol
; 204(3): 420-434, 2018 12.
Artigo
Inglês
| MEDLINE | ID: mdl-30342092
12.
The uniqueness of subunit α of mycobacterial F-ATP synthases: An evolutionary variant for niche adaptation.
J Biol Chem
; 292(27): 11262-11279, 2017 07 07.
Artigo
Inglês
| MEDLINE | ID: mdl-28495884
13.
The FGFR inhibitor PD173074 binds to the C-terminus of oncofetal HMGA2 and modulates its DNA-binding and transcriptional activation functions.
FEBS Lett
; 597(15): 1977-1988, 2023 08.
Artigo
Inglês
| MEDLINE | ID: mdl-37259564
14.
GaMF1.39's antibiotic efficacy and its enhanced antitubercular activity in combination with clofazimine, Telacebec, ND-011992, or TBAJ-876.
Microbiol Spectr
; 11(6): e0228223, 2023 Dec 12.
Artigo
Inglês
| MEDLINE | ID: mdl-37982630
15.
Mutational Analysis of Mycobacterial F-ATP Synthase Subunit δ Leads to a Potent δ Enzyme Inhibitor.
ACS Chem Biol
; 17(3): 529-535, 2022 03 18.
Artigo
Inglês
| MEDLINE | ID: mdl-35148057
16.
Atomic solution structure of Mycobacterium abscessus F-ATP synthase subunit ε and identification of Ep1MabF1 as a targeted inhibitor.
FEBS J
; 289(20): 6308-6323, 2022 10.
Artigo
Inglês
| MEDLINE | ID: mdl-35612822
17.
Structural and Mechanistic Insights into Mycobacterium abscessus Aspartate Decarboxylase PanD and a Pyrazinoic Acid-Derived Inhibitor.
ACS Infect Dis
; 8(7): 1324-1335, 2022 07 08.
Artigo
Inglês
| MEDLINE | ID: mdl-35731701
18.
Atomic structure of the regulatory TGS domain of Rel protein from Mycobacterium tuberculosis and its interaction with deacylated tRNA.
FEBS Lett
; 595(24): 3006-3018, 2021 12.
Artigo
Inglês
| MEDLINE | ID: mdl-34808002
19.
Targeting Mycobacterial F-ATP Synthase C-Terminal α Subunit Interaction Motif on Rotary Subunit γ.
Antibiotics (Basel)
; 10(12)2021 Nov 26.
Artigo
Inglês
| MEDLINE | ID: mdl-34943667
20.
Atomic structure of, and valine binding to the regulatory ACT domain of the Mycobacterium tuberculosis Rel protein.
FEBS J
; 288(7): 2377-2397, 2021 04.
Artigo
Inglês
| MEDLINE | ID: mdl-33067840